Gay marriage opponents ask court to intervene

SAN FRANCISCO (AP) ? Lawyers for the sponsors of California's same-sex marriage ban have filed an emergency motion asking the U.S. Supreme Court to overrule the federal appeals court that on Friday freed the state to issue marriage licenses to gay couples.

Attorneys with the Arizona-based Alliance Defending Freedom said they submitted the petition on Saturday to Justice Anthony Kennedy, who handles motions dealing with the 9th Circuit Court of Appeals.

Senior Counsel Austin Nimocks says a three-judge 9th Circuit panel acted prematurely and unfairly when it lifted the hold on same-sex marriages it had put in place while a challenge to the ban made its way through the courts.

Nimocks says the Supreme Court's consideration of the case is not done yet because his clients still have 22 days to ask the justices to reconsider their decision holding that Proposition 8's backers did not have legal authority to defend the ban.

Source: http://news.yahoo.com/gay-marriage-opponents-ask-court-intervene-210730914.html

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South Africa: Mandela still in critical condition

JOHANNESBURG (AP) ? A granddaughter of Nelson Mandela says the former South African president remains in critical condition.

The granddaughter, Ndileka Mandela, made the comment Thursday when she and other family members stepped outside the Pretoria hospital treating 94-year-old Mandela to collect flowers and messages of support that were left outside the building.

Ndileka Mandela also describes her grandfather's condition as stable, indicating it had not changed since the government said on Sunday that Mandela's health had deteriorated to a critical state.

The granddaughter says it has been a difficult situation for the family, especially because they are coping with Mandela's illness in the public eye.

Source: http://news.yahoo.com/south-africa-mandela-still-critical-condition-082546750.html

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Pre-caffeine tech: Instagram fight, insane TVs?

Technology

Helen A.S. Popkin NBC News

June 25, 2013 at 9:34 AM ET

io9.com

Our pre-caffeine roundup is a collection of the hottest, strangest, and most amusing stories of the morning.

Are beetles really stoking Colorado fires? Let's find out, while we look at some pictures of bugs!

Finally! Real-life super-powered 'exosuit': Better, faster, stronger ... softer!

Ellen Page, star of "Juno" and a bunch of other movies, says this video game totally "ripped off" her likeness.

Yoinks! Facebook Reader won't Be the Google replacement of your dreams.

That said, why does everyone except Google want to build a reader?

People freaking out over Mark Zuckerberg's dog don't seem to know that's what those kind of dogs look like when they grow up.

Here's the latest on Bitcoin blah blah blah.

Are people with laptops and big phones more assertive than iPod and feature-phone users? Yes, according to this survey.

Instagram fight! Instagram fight! Rihanna and Liz Jones in an Instagram fight!

In closing: The Most Insane Television Sets in History!

Compiled by Helen A.S. Popkin, who invites you to join her on Twitter and/or Facebook.

Source: http://feeds.nbcnews.com/c/35002/f/663301/s/2dde6c6e/l/0L0Snbcnews0N0Ctechnology0Cpre0Ecaffeine0Etech0Einstagram0Efight0Einsane0Etvs0E6C10A435781/story01.htm

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Cracking Cancer's Secret Code: Oncologist Searches for Breast ...

Triple-negative breast cancer has been defined by what it is not, but Dr. Jennifer Pietenpol and her team has identified six different subtypes of the disease.

Over the last decade, oncologist Jennifer Pietenpol has been trying to decode and kill a difficult-to-treat type of breast cancer. Known as triple-negative breast cancer, this form of the disease can be highly aggressive and resistant to chemotherapy.

The cancer, which accounts for 10 to 20 percent of all breast cancers in the United States, is also a deadly genetic riddle that doctors find easiest to describe in terms of what it is not. ?Between 75 to 85 percent of breast cancers express one of three clear targets for therapy,? says Pietenpol, who runs the Vanderbilt-Ingram Cancer Center in Nashville, Tenn. ?But with triple-negative cancer, there is nothing to attack and patients go into a standard of care that involves combinations of chemotherapy that have been determined by experiment. We felt that in this era of precision medicine, we should get a better handle on the treatment.?

Pietenpol and her team have collected and analyzed more than 600 cases of triple-negative breast cancer so far, and their results have defined six biological subtypes of the disease. This breakthrough could help scientists apply existing drugs and procedures to attack the cancer, develop new ones, and map out treatment.

Last year, GE?s Healthymagination Challenge, an open innovation quest that seeks to find and fund the best new ideas in breast cancer detection and treatment, gave Pietenpol?s team $100,000 to finance more science. ?We are beginning to get that molecular information from an individual patient?s tumor,? she says. ?This is helping us guide therapy and align it with patients. Every bit of additional funding helps to accelerate this further.?

Doctors divide breast cancer into four groups, based on what is driving tumor growth. The vast majority of breast cancers use the estrogen receptor, the progesterone receptor or the HER2 pathway for growth. ?When we see this, we can apply existing therapy, like Tamoxifen,? Pietenpol says.

Her research group and other teams are now looking for similar tools and targets to destroy the fourth type of breast cancer, triple-negative cancer. ?Our task is to understand how these tumor cells grow, find their Achilles? heel, and how we can hit it,? she says.

Pietenpol starts by looking at the different pathways the tumor cells appear to use to signal growth, pairs that information with genetic data about how the cells mutate and then tests the hypotheses in her lab. ?In cancer, we want to move to predictive oncology where we can use molecular information to better guide treatment,? she says.

Pietenpol?s team has already pinned six unique targets to triple-negative cancer?s back. One of them, an androgen receptor, could expose as many as 10 percent of triple-negative cancer cases to attack. But additional targets will likely be smaller. ?As we go more into precision medicine, the fraction of people with any given molecular subtype will get smaller and smaller,? she says. ?This is where we are going, using much more precision therapy where no two tumors are going to be alike.?

Pietenpol?s team has started designing clinical trials for each of the six subtypes. She says that ?androgen-receptor antagonists? used for treating prostate cancer could be effective against the androgen receptor subset her team discovered. ?We are continuing to accelerate this, but we have a lot of work to do,? she says. ?We?ve just begun to uncover these lower hanging fruits.?

Source: http://www.gereports.com/cracking-cancers-secret-code/

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Preventing skin cancer in children begins with the right sunscreen

June 25, 2013 ? It is well known that exposure to the sun is the key risk factor for developing skin cancer. And while most parents are aware that applying sunscreen to their children is important, many go wrong by not taking the time to choose the most effective sunscreen, or they don't understand the limitations of sunscreen.

"Young, developing skin may be particularly vulnerable to UV rays," said Lawrence Eichenfield, MD, chief of pediatric and adolescent dermatology at Rady Children's Hospital-San Diego. "If your child is getting intense sun exposure playing outdoors, she's in danger of developing melanoma -- the most serious type of skin cancer -- even if she has what appears to be a healthy tan."

Parents should consider the following to make the best sunscreen choice:

?Sun Protection Factor (SPF) -- Pick an SPF of 15 or higher. The higher the SPF, the greater the protection from sunburn caused mostly by UVB rays, not UVA. Also, the higher SPF does not increase the length of time for sun exposure.

?UVA protection -- Most sunscreens protect against UVB, but not UVA. UVA has a longer wavelength, less energy, but is more mutagenic (i.e. cancer-causing) than UVB. Products that contain Oxobenzone or Avobenzone (Parsol) can block UVA, but may break down under the sun and thus only offers no more than 4 hours of UVA protection. Mexoryl is a newer addition to sunscreen ingredients that does not break down in the sun. Another new ingredient, Helioplex, helps stabilize Parsol and allows up to 6 hours of UVA protection. Look for these ingredients in your sunscreen or the AAD SEAL OF RECOGNITION on sunscreen products to ensure protection against UVA.

?Hypoallergenic sunscreen -- Most allergic reactions against sunscreen are caused by para-aminobenzoid acid (PABA). If your child has a reaction against sunscreen, try products that do not contain PABA, dyes or perfumes. Also, sunscreens containing titanium dioxide or zinc dioxide provide physical block that reflects both UVA and UVB and has no chemical ingredients suitable for those with prior reactions to sunscreen.

?Non-comedogenic sunscreen -- For oily skin, try products that are labeled with "won't clog pores" or "non-comedogenic" to reduce acne caused by sunscreen.

?Lip sunscreen -- It is also important to protect your lips from the sun! Choose a lip balm with SPF 15 or higher.

?New advances in sunscreen technology -- Scientists are coming up with sunscreen containing vitamins C and E, which help boost the skin's defenses against UV damage. There is also a sunscreen "pill," called Heliocare, that can offer up to 3 hours of protection. These are currently meant to supplement sunscreens and not to replace them.

Of course, the best way to avoid sunburn and skin damage is to avoid the sun entirely, especially between 10am and 4pm, the period of the day when sunrays are strongest.

"As a dermatologist I see the effects that sun damage causes to skin; damage can occur at any age and babies can be even more susceptible to the sun," said Dr. Eichenfield. "I recommend parents and babies practice sun protection every day to avoid a lifetime of cumulative sun exposure. It is also important to use a variety of sun protection measures to protect themselves and their children when out in the sun including proper application of a physical sunblock, protective clothing, and seeking shade during peak sun hours."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/xEtH98EknJY/130625140931.htm

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Telefonica to sell its Irish operations to Three for $1.1 billion

Think you're carrying a tad too much debt? Spanish telecom giant Telefónica wants to reduce its red ink to 47 billion euros ($62 billion) by the end of the year, so it's decided to sell its Irish mobile and broadband business to Hutchison Whampoa's Three for 850 million euros ($1.1 billion). If regulators approve the deal, it'll let Telefónica hack about 750 million euros of debt from its books, while giving Three a 37.5 percent share of the nation's mobile business and a strong number two position behind Vodafone. The deal follows a £200 million ($273 million) sale of Telefónica's fixed phone line business to Sky. Considering the whopping level of debt, though, that may be just the start.

[Image credit: Wikimedia Commons]

Filed under: Cellphones, Wireless, Internet

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Via: WSJ (subscription)

Source: http://www.engadget.com/2013/06/24/telefonica-sells-its-irish-mobile-business-to-three/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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'Mad Men' stars in not-so-'60s roles

TV

Ree Hines TODAY contributor

June 22, 2013 at 11:11 AM ET

They look sleek, sexy and dapper in their 1960s finery, but the cast of "Mad Men" isn't always so polished. In fact, sometimes when the stars who bring Don Draper, Roger Sterling and the rest of the characters to life aren't playing the roles they're most famous for, they're barely recognizable.

Before you say "so long" to the Sterling Cooper & Partners gang for the season on Sunday night, take a look at our roundup of some of the (not-so-) familiar faces.

AMC / NBC

Jon Hamm as Don Draper on "Mad Men" and Abner on "30 Rock."

Don Draper's made some serious mistakes on "Mad Men" this season, but thankfully, the look on the right isn't one of them. No, that's just John Hamm spoofing old-timey, distasteful comedies in an "Alfie and Abner" skit from a live episode of "30 Rock."

AMC / Netflix

John Slattery as Roger Sterling on "Mad Men" and Dr. Norman on "Arrested Development."

If it looks like Roger Sterling has seen better days in the second shot, that's because the actor who plays him, John Slattery, took on the part of a washed up, dirty doctor in the recent return of "Arrested Development."

AMC / CBS

Elisabeth Moss as Peggy Olson on "Mad Men" and Cynthia Parks on "Picket Fences."

Peggy Olson's grown into quite the copywriter at Sterling Cooper & Partners, but way before that, actress Elisabeth Moss hit the small screen when she was still small. She made her first appearance in the quirky dramedy "Picket Fences" in 1992.

AMC / 20th Century Television

Vincent Kartheiser as Pete Campbell on "Mad Men" and Connor on "Angel."

Even Pete Campbell -- or rather Vincent Kartheiser -- had a fresh-faced look on TV back in the day. Long before joining "Mad Men," Kartheiser played Connor, the non-vamp son of the fang-bearing lead, on "Angel."

AMC / FOX

Christina Hendricks as Joan Harris on "Mad Men" and Saffron on "Firefly."

If you're a fan of Joan Harris' just-so hair, tailored dresses and crimson lipstick, then Christina Hendricks' turn on "Firefly" might not interest you. But if you want to see Hendricks' range (and don't mind seeing her in far fewer clothes), then be sure to catch both of her decade-old episodes.

AMC / Capri Films

Jessica Pare as Megan Draper on "Mad Men" and Jennifer on "Suck."

Yikes! Megan Draper goes from Don's secretary to wife on "Mad Men," but actress Jessica Pare went from alive to undead in the movie "Suck."

AMC / NBC

Alison Brie as Trudy Campbell on "Mad Men" and Annie Edison on "Community."

When actress Alison Brie isn't playing the part of Pete's long-suffering wife, Trudy Campbell, she's laughing it up as the brainy and beautiful Annie on the sitcom "Community."

AMC / Warner Bros. Pictures

Jared Harris as Lane Pryce on "Mad Men" and Moriarty in "Sherlock Holmes: A Game of Shadows."

Rest in peace, Lane Pryce. Fans of the fallen character can see actor Jared Harris back in action in the 2011 film "Sherlock Holmes: A Game of Shadows," playing the ultimate match for the sleuth -- the devious Professor Moriarty.

The season six finale of "Mad Men" airs Sunday at 10 p.m. on AMC.

Source: http://www.today.com/entertainment/mad-men-stars-not-so-60s-roles-6C10411625

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